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The incomplete digestion of gliadin results in the formation of two crucial peptides: The 33-mer immunogenic peptide (pp.57 - 89), which triggers a strong adaptive immune response, and a 25-amino acid peptide (pp.31 - 55), known to stimulate interleukin-15 (IL-15) production in both enterocytes and dendritic cells
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One of the most prominent miRNAs upregulated in CRC is miR-21, commonly referred to as an “oncomiR.” miR-21 has been shown to mediate resistance to 5-FU by downregulating components of the mismatch repair pathway
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