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In healthy tissue, BPC-157 appears to maintain nitric oxide homeostasis by modestly increasing eNOS activity while suppressing iNOS

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Additionally, low-dose berberine protected PC12 cells from 6-hydroxydopamine (6-OHDA, Parkinson’s disease-related neurotoxin)-induced cytotoxicity and apoptosis, whereas high-dose berberine showed no neuroprotective activity