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Currently, silymarin is mainly used as a remedy for Amanita phalloides (death cup fungus) intoxication where silymarin plays a role in hepatoprotection through the mechanisms such as stopping the α-amanitin entero-hepatic cycle, prevention of phalloidin and α-amanitin binding to membranes of hepatocyte, and antagonising the α-amanitin membrane transporting (18,24)