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Its pathophysiology centers on chronic hyperuricemia and dysregulated uric acid metabolism (Stiburkova and Ichida, 2025

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CPS for HCC patients include the high serum tumor cells’ products as massive lactate production (Warburg effect), 41 metalloproteinase (MMP) enzymes (facilitating invasion and metastasis), vascular endothelial growth factor (facilitating angiogenesis), exosomes, free radicals (reactive oxygen species and reactive nitrogen species), and others