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The “D-retro-inverso” design replaces all L-amino acids with D-amino acids and reverses the sequence — a structural strategy that preserves the side-chain topology of the original FOXO4 binding region while making the peptide resistant to proteolytic degradation, dramatically extending plasma half-life compared to the natural L-form

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After a week of acclimatization, they were divided into five groups of 10 mice each, maintaining equal gender distribution

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