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While GHK-Cu treatment alone did not cause any visible histological changes or toxicity, pretreatment with GHK-Cu markedly attenuated these pathological alterations, resulting in a significantly reduced lung injury score compared to the LPS-only group
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The latter can occur naturally, such as the opioid peptide dermorphin isolated from frog skin, peptidoglycans of some microorganisms, or venom peptides—conotoxins containing D -tryptophan ( D -Trp), D -leucine ( D -Leu), etc
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