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I can't say for sure why it happens, but I think it's a number of factors - modern-day stress, low-fat diets, high sugar consumption and alcohol
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In female C57BL/6 mice with DHEA (Dehydroepiandrosterone) and high-fat diet–induced PCOS, the Phosphodiesterase-4 inhibitor roflumilast improved ovarian function by increasing primary, preantral, and antral follicles, reducing cystic follicles and testosterone levels, as well as enhancing progesterone levels (Ji et al., 2023)
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