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These observations suggest that aminochrome is involved in the alpha synuclein-dependent inhibition of CMA autophagy because aminochrome induces the formation of α -synuclein protofibrils, such as the A53T mutant (Figure 10)
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Considering the eating and drinking habits, the adaptive cytoprotection in the gastrointestinal tract starts in the upper parts, in the stomach and duodenum, and may beneficially affect other parts (and thereby, adaptive cytoprotection occurs between stomach → stomach
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