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Impaired insulin signaling, diminished mitochondrial oxidative capacity, lipid peroxidation, ferroptosis, and microbial dysbiosis not only exacerbate hepatic steatosis but also facilitate the progression from simple steatosis to more severe forms of the disease, such as NASH and cirrhosis [51,56,63,64,65,66,67]
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The 2.4 mg dose, which became the standard dose carried forward into phase 3 trials, produced approximately 8% to 9% weight loss in 26 weeks
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