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Microbiota changes in people, however, are heterogeneous, with food intake being one major determinant of gut microbial composition that might confound the apparent exercise-related effects (Zhou et al., 2024)

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Accordingly, α-PD-1 or α-PD-L1 treatment, as well as blockade of CTLA-4, enhances the efficacy of inhibitors targeting GLS1 (91, 102), glutamine-utilizing enzymes (74, 75) or glutamine uptake in vivo (104)