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The insulin receptor signaling involves the insulin receptor substrate- (IRS-) 1-mediated activation of PI3K (phosphatidylinositol-3-kinase), resulting in Akt2 activation, inhibition of the Akt2 substrate AS160 (Akt substrate 160, a GTPase-activating protein for Rabs), and consequently, the activation of Rab8a and Rab14 GTPases in muscle cells [71]

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[DOI] [PubMed] [Google Scholar] 60.Wang Y., Zhang S., Li C., Li B., Ouyang L