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The complexity of the DPP4-dependent potentiation of Rantes activity is underscored by observations that sDPP4 still potentiated the ability of Rantes [3–68] to activate T cells in vitro, suggesting enzyme-independent cooperatively between sDPP4 and chemokine activity (125)

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Under pathological conditions, disruption of TFAM can lead to mtDNA mispackaging, a massive release of damaged mtDNA, and down-regulation of TFAM also reduces the stability of the mtDNA mimetic nuclear structure (West et al., 2015)