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Compounds in the samples analyzed in 2024 were identified using a liquid chromatograph with quadrupole TOF mass spectrometer (LCMS9050-Q-TOF, Shimadzu Corporation, Kyoto, Japan)
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Second-line treatments have also been designed over the past few years, including regorafenib (antiangiogenesis) (El-Khoueiry et al., 2017), and ramucirumab (against VEGFR2) (Zhu et al., 2019)
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