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Pharmaceutical pen formulations of semaglutide and tirzepatide are the only exceptions, tolerating room temperature for weeks due to specialized stabilizers

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The major classes of analgesics include nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, local anesthetics, and gabapentinoids, each operating via distinct molecular mechanisms yet converging on the suppression of nociceptive signaling at the site of tissue injury, either along peripheral nerves or within central pain-processing pathways