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Mechanisms of Tirzepatide: GLP-1 receptors GIP receptors This dual action produces powerful effects on appetite regulation, insulin sensitivity, blood sugar control, and energy balance

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Moreover, as discussed in the CY 2026 PFS proposed rule (90 FR 32664), section 1899(b)(2)(D) of the Act requires participating ACOs to include primary care ACO professionals that are sufficient for the number of Medicare FFS beneficiaries assigned to the ACO and that, at a minimum, the ACO shall have at least 5,000 such beneficiaries assigned to it under section 1899(c) of the Act in order to be eligible to participate in the Shared Savings Program