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As diabetes progressively worsens, pancreatic beta cells begin to “burn out,” and exogenous insulin is often necessary in late-stage disease (Prentki 2006

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[8] Novo Nordisk announced late at the 2025 European Association for the Study of Diabetes (EASD) annual meeting that in the REDEFINE 1 study, [9] cagrilintide provided clinically significant weight loss, with a mean reduction in body weight of 11.8% compared to 2.3% with placebo after 68 weeks, considering adherence of all participants to treatment