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3.1.6 Effects on cytokines Moderate-intensity exercise exerts a wide range of effects on cytokines, especially in the modulation of critical cytokines like IL-6, TNF-α, and IL-10.The release of IL-6 from contracting skeletal muscle, first identified as a ‘myokine’ nearly two decades ago, represents a hallmark cytokine response to endurance exercise

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(PubMed) Salih BA, Abasiyanik FM